What is Soft Tissue Sarcoma

About soft tissue sarcoma

Soft tissue sarcoma is a cancer that begins in the soft tissues of the body. This can include the muscles, tendons, fat, blood vessels, or other supporting tissue.

Soft Tissue Sarcoma Infographic

Soft tissue sarcoma is considered a rare cancer. Every year, approximately 12,000 people are diagnosed with soft tissue sarcoma in the U.S.

STS is rare, so it’s important to find a specialist who has experience treating it. For information about finding a specialist, click here.

Types of soft tissue sarcoma

There are many different types of soft tissue sarcoma, which are called subtypes.

According to the American Cancer Society, there are more than

There are 50 different subtypes of soft tissue sarcoma

Different subtypes of soft tissue sarcoma are usually associated with certain locations in the body and types of tissue.

Common types of soft tissue sarcoma in adults include undifferentiated pleomorphic sarcomaUndifferentiated pleomorphic sarcoma: A subtype of soft tissue sarcoma that can occur anywhere in the body, including legs, arms, and back of abdomen.X, liposarcomaLiposarcoma: A subtype of soft tissue sarcoma that develops in the fat cells of the body.X, and leiomyosarcomaLeiomyosarcoma (lī-ō-ˌmī-ō-sär-ˈkō-mə): A subtype of soft tissue sarcoma that starts in the smooth muscle cells and is most common in the uterus, abdomen, or pelvis.X.

Symptoms of soft tissue sarcoma

Soft tissue sarcoma can appear almost anywhere in the body, and can start as a lump with no other symptoms.

Each subtype is different, so people have different experiences with symptoms, diagnosis, and treatment.

The first signs of sarcoma can be:

  • A lump that has grown over a period of time
  • Worsening abdominal pain
  • Uncomfortable swelling
  • Limited mobility
  • Pain that feels like a pulled muscle
Find a soft tissue sarcoma specialist

Find a soft tissue sarcoma specialist

Soft tissue sarcoma is rare, so it’s important to find doctors who have experience diagnosing and treating this disease.

At sarcoma centers, you can find doctors who are experts in treating soft tissue sarcoma.

Doctors at sarcoma centers work as a team to find the best path forward for their patients. These centers may also help you connect with sarcoma support groups.

If you are looking for a doctor who treats sarcoma, there are resources available to help you in your search.

Click here to see the Sarcoma Center Map from Sarcoma Alliance

Click here to see the Sarcoma Treatment Center Map from Sarcoma Foundation of America

Get the most out of talking to your doctor

Treatment decisions are a team effort between you and your doctor. The right questions can make all the difference in helping you understand your disease and your treatment options.

Don’t hesitate to speak up!

Make sure to talk to your doctor about STS

You’re going to hear a lot of new information, so it’s normal to feel confused. It’s okay to have questions and ask your doctors to repeat what they have already said. They are there to help you with any questions or concerns, so don't hold back!

TIP: Take notes or ask your doctor for permission to make an audio recording

Record your visit with your doctor

Bring a notebook or audio recorder to your visit. A friend or family member can help you with this.

Most smartphones can make an audio recording, which can help you focus on listening during your visit. Review your doctor’s words at home whenever you need to.

If you plan to make an audio recording of your conversation, make sure to ask your doctor for permission first.

Questions you can ask your doctor

  • Who will be involved in my treatment?
  • What is your experience treating patients with sarcoma?
  • How often should I come in for additional tests or scans?
  • Can you recommend additional resources that would help educate me about my disease and treatment?
  • How will treatment affect my family, work, travel, etc.?
  • What can I expect during treatment?
  • What side effects should I expect with LARTRUVO + doxorubicin?

You should tell your doctor

  • If you are pregnant or breastfeeding, may be pregnant, or plan to become pregnant
  • If you are taking any medications, including prescription and over-the-counter medications
  • If you have received any past treatments for sarcoma or another type of cancer
  • If you have any other medical conditions
  • If you have ever experienced any allergic reactions or unusual responses to medication
Indication and Important Safety Information

LARTRUVO (olaratumab) is a prescription medicine used with a type of chemotherapy called doxorubicin to treat adult patients with soft tissue sarcoma (STS) for whom doxorubicin is appropriate and who cannot be cured with radiation or surgery.

There is an ongoing study to confirm how LARTRUVO works in combination with doxorubicin.

What is the most important information I should know about LARTRUVO?
  • Infusion reactions related to injecting LARTRUVO have occurred. Most of these reactions happened during or after the first or second LARTRUVO infusion. Signs and symptoms of infusion reactions include flushing, shortness of breath, severe trouble breathing, or fever/chills. In severe cases, severe low blood pressure, anaphylactic shock (a severe, potentially life-threatening allergic reaction), or cardiac arrest (abrupt loss of heart function) may occur. Tell your doctor if you have any of these symptoms. Your healthcare team will monitor you for these side effects. In the case of a severe infusion reaction, your LARTRUVO treatment will have to be immediately and permanently stopped.
  • LARTRUVO can harm your unborn baby. You should avoid getting pregnant, and use effective birth control while receiving LARTRUVO and for at least 3 months after stopping LARTRUVO.
What are the most common side effects of LARTRUVO?
  • The most common side effects reported in patients treated with LARTRUVO when given in combination with doxorubicin were nausea; tiredness or weakness; pain in the muscles, joints, and bones; sores and swelling of the mouth and digestive tract; hair loss; vomiting; diarrhea; decreased appetite; stomach pain; weakness, numbness, or pain in the hands and feet; and headache.
  • The most common changes to blood tests were low white blood cell count, low platelet count, high blood sugar, increased blood clotting time, low blood potassium level, and low blood phosphate level.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/safety/medwatch or call 1-800-FDA-1088.

What should I tell my doctor before receiving treatment with LARTRUVO?

Before you receive LARTRUVO, tell your doctor if you:

  • Are pregnant or may be pregnant. If you become pregnant during treatment, discuss this with your doctor.
  • Are breastfeeding: your doctor will tell you not to breastfeed during LARTRUVO treatment and for at least 3 months after stopping LARTRUVO.

Tell your doctor about all the medications you are taking, including prescription and over-the-counter medications.

LARTRUVO is available by prescription only.

Please see full Prescribing Information for additional information about LARTRUVO.